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Abstract Purpose of Review To review carnitines role in migraine and headache, present a case of a patient with intractable chronic migraine refractory to medications but exquisitely responsive to mitochondrial cofactors with a particularly prompt response to L-carnitine supplementation with dose response, and suggest scenarios where L-carnitine could be considered for prophylactic treatment in migraine and intractable headache with migraine features

Although it shows promise for potential applications in stress management and sleep related peptide therapy, there is still much to learn about its workings and uses

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Trafficking also contributes to the cleansing and replenishment of mitochondria in the periphery (Schwarz, 2013)

Never double up doses to make up for a missed treatment